Issue 6, 2012

Effective resolution of 1-phenyl ethanol by Candida antarctica lipase B catalysed acylation with vinyl acetate in protic ionic liquids (PILs)

Abstract

Herein we report the novel use of essentially anhydrous protic ionic liquids (PILs) as reaction media for performing the smooth kinetic resolution of 1-phenylethanol by Candida antarctica lipase B (CaLB) catalysed acylation with vinyl acetate at 40 °C. Good rates and high enantioselectivities (92–>99%) were observed with suspensions of both the free enzyme and cross-linked enzyme aggregates (CLEAs) of CaLB.

Graphical abstract: Effective resolution of 1-phenyl ethanol by Candida antarctica lipase B catalysed acylation with vinyl acetate in protic ionic liquids (PILs)

Article information

Article type
Communication
Submitted
09 Feb 2012
Accepted
20 Mar 2012
First published
21 Mar 2012

Green Chem., 2012,14, 1584-1588

Effective resolution of 1-phenyl ethanol by Candida antarctica lipase B catalysed acylation with vinyl acetate in protic ionic liquids (PILs)

A. P. de los Ríos, F. van Rantwijk and R. A. Sheldon, Green Chem., 2012, 14, 1584 DOI: 10.1039/C2GC35196J

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