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Issue 26, 2016
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Organocatalytic asymmetric addition of alcohols to cyclic trifluoromethyl ketimines: highly enantioselective synthesis of chiral N,O-ketals

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Abstract

A highly enantioselective addition of alcohols to cyclic trifluoromethyl ketimines is developed catalyzed by quinine-thiourea, giving biologically interesting N,O-ketals in up to 99% yield and 96% ee.

Graphical abstract: Organocatalytic asymmetric addition of alcohols to cyclic trifluoromethyl ketimines: highly enantioselective synthesis of chiral N,O-ketals

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Publication details

The article was received on 26 Apr 2016, accepted on 16 May 2016 and first published on 17 May 2016


Article type: Communication
DOI: 10.1039/C6OB00890A
Citation: Org. Biomol. Chem., 2016,14, 6193-6196
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    Organocatalytic asymmetric addition of alcohols to cyclic trifluoromethyl ketimines: highly enantioselective synthesis of chiral N,O-ketals

    D. Zhou, X. Yu, J. Zhang, W. Wang and H. Xie, Org. Biomol. Chem., 2016, 14, 6193
    DOI: 10.1039/C6OB00890A

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