Issue 1, 2012
From the journal:

Organic & Biomolecular Chemistry

Enhancement of affinity in molecular recognition viahydrogen bonds by POSS-core dendrimer and its application for selective complex formation between guanosine triphosphate and 1,8-naphthyridine derivatives†

Kazuo Tanaka,a   Masahiro Murakami,a   Jong-Hwan Jeona  and  Yoshiki Chujo*a  

* Corresponding authors

a Department of Polymer Chemistry, Graduate School of Engineering, Kyoto University, Katsura, Nishikyo-ku, Kyoto, Japan
E-mail: chujo@chujo.synchem.kyoto-u.ac.jp
Fax: (+81) 75-383-2605
Tel: (+81) 75-383-2604

Abstract

We report that a polyhedral oligomeric silsesquioxane (POSS) core in a dendrimer can enhance the affinity of the molecular recognition via hydrogen bonds between 1,8-naphthyridine and guanosine nucleotides. The complexation of the naphthyridine ligands with a series of guanosine nucleotides was investigated, and it is shown that the POSS core should play a significant role in the stabilization of the complexes via hydrogen bonds. Finally, we demonstrate that the 1,8-naphthyridine ligand can selectively recognize guanosine triphosphate by assisting with the POSS-core dendrimer.

Graphical abstract: Enhancement of affinity in molecular recognition via hydrogen bonds by POSS-core dendrimer and its application for selective complex formation between guanosine triphosphate and 1,8-naphthyridine derivatives

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Article information

DOI
https://doi.org/10.1039/C1OB06630G
Article type
Paper
Submitted
24 Sep 2011
Accepted
12 Oct 2011
First published
01 Nov 2011

Org. Biomol. Chem., 2012,10, 90-95

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Enhancement of affinity in molecular recognition via hydrogen bonds by POSS-core dendrimer and its application for selective complex formation between guanosine triphosphate and 1,8-naphthyridine derivatives

K. Tanaka, M. Murakami, J. Jeon and Y. Chujo, Org. Biomol. Chem., 2012, 10, 90 DOI: 10.1039/C1OB06630G

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