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Issue 1, 2012
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Asymmetric cyanation of nitroalkenes catalyzed by a salen–titanium catalyst

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Abstract

The salen–Ti complex catalyzed cyanation of nitroolefins was accomplished via the silyl nitronate intermediate for the synthesis of chiral β-nitronitriles with e.r. up to 92 : 8 and high yields (up to 90%). The catalyst also kept a high turnover frequency at room temperature. The yield and enantioselectivity of the protocol were slightly affected even in a 10 mmol scale.

Graphical abstract: Asymmetric cyanation of nitroalkenes catalyzed by a salen–titanium catalyst

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Publication details

The article was received on 04 Jun 2011, accepted on 08 Sep 2011 and first published on 08 Sep 2011


Article type: Paper
DOI: 10.1039/C1OB05899A
Citation: Org. Biomol. Chem., 2012,10, 83-89
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    Asymmetric cyanation of nitroalkenes catalyzed by a salen–titanium catalyst

    L. Lin, W. Yin, X. Fu, J. Zhang, X. Ma and R. Wang, Org. Biomol. Chem., 2012, 10, 83
    DOI: 10.1039/C1OB05899A

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