Issue 2, 2008

Synthesis and characterization of the 5-methyl-2′-deoxycytidine glycol–dioxoosmium–bipyridine ternary complex in DNA

Abstract

It has been established that approximately 80% of a 5-methyl-2′-deoxycytidine glycol–dioxoosmium(VI)–bipyridine ternary complex, which is known to be produced as one of various consequences of oxidative damage of DNA and is formed in a key step of a recently developed DNA methylation detection method, has the 5R,6S configuration.

Graphical abstract: Synthesis and characterization of the 5-methyl-2′-deoxycytidine glycol–dioxoosmium–bipyridine ternary complex in DNA

Supplementary files

Article information

Article type
Communication
Submitted
25 Oct 2007
Accepted
27 Nov 2007
First published
07 Dec 2007

Org. Biomol. Chem., 2008,6, 269-271

Synthesis and characterization of the 5-methyl-2′-deoxycytidine glycol–dioxoosmium–bipyridine ternary complex in DNA

T. Umemoto and A. Okamoto, Org. Biomol. Chem., 2008, 6, 269 DOI: 10.1039/B716400A

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