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Issue 2, 2008
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Fluorescence and electrochemical detection of pyrimidine/purinetransversion by a ferrocenyl aminonaphthyridine derivative

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Abstract

A novel hydrogen bond-forming ligand for pyrimidine/purinetransversion, which contains both a fluorescent naphthyridine moiety and a ferrocenyl group as an electrochemical indicator, is described. Hydrogen bond-mediated recognition for a target nucleobase at an abasic site in a DNA duplex is confirmed by both fluorescence and electrochemical measurements. The analysis by fluorescence titration reveals that the ligand shows significant fluorescent quenching upon formation of a 1 : 1 complex with the target nucleobase opposite the abasic site, and the selectivity is in the order of cytosine > thymine > adenine, guanine, reflecting the stability of the hydrogen bond formation.

Graphical abstract: Fluorescence and electrochemical detection of pyrimidine/purinetransversion by a ferrocenyl aminonaphthyridine derivative

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Publication details

The article was received on 29 Oct 2007, accepted on 23 Nov 2007 and first published on 04 Dec 2007


Article type: Communication
DOI: 10.1039/B716682F
Citation: Org. Biomol. Chem., 2008,6, 266-268
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    Fluorescence and electrochemical detection of pyrimidine/purinetransversion by a ferrocenyl aminonaphthyridine derivative

    K. Morita, Y. Sato, T. Seino, S. Nishizawa and N. Teramae, Org. Biomol. Chem., 2008, 6, 266
    DOI: 10.1039/B716682F

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