Synthesis, structure and biological evaluation of bis salicylaldehyde-4(N)-ethylthiosemicarbazone ruthenium(III) triphenylphosphine

R. Prabhakaran; P. Kalaivani; R. Jayakumar; M. Zeller; A. D. Hunter; S. V. Renukadevi; E. Ramachandran; K. Natarajan

doi:10.1039/C0MT00062K

Synthesis, structure and biological evaluation of bis salicylaldehyde-4(N)-ethylthiosemicarbazone ruthenium(iii) triphenylphosphine†

R. Prabhakaran,*^a P. Kalaivani,^a R. Jayakumar,^b M. Zeller,^c A. D. Hunter,^c S. V. Renukadevi,^a E. Ramachandran^a and K. Natarajan*^a

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^a Department of Chemistry, Bharathiar University, Coimbatore, India
E-mail: rpnchemist@gmail.com, k_natraj6@yahoo.com

^b Department of Zoology, Bharathiar University, Coimbatore, India

^c Department of Chemistry, Youngstown State University, Youngstown, OH 44555-3663, USA

Abstract

Bis salicylaldehyde-4(N)-ethylthiosemicarbazone ruthenium(III) triphenylphosphine [Ru(Sal-etsc)(H-Sal-etsc)(PPh₃)] was synthesized and structurally characterized by spectral and X-ray crystallographic studies and it showed 100% inhibition on the DPPH radical. It also exhibited a significant lymphocyte activity and inhibitory effect on the lung carcinoma A549 cell.

Metallomics

Synthesis, structure and biological evaluation of bis salicylaldehyde-4(N)-ethylthiosemicarbazone ruthenium(iii) triphenylphosphine†

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