Issue 6, 2012

Different cardiovascular protective effects of quercetin administered orally or intraperitoneally in spontaneously hypertensive rats

Abstract

We tested whether the administration procedure of quercetin affects its metabolite profile and antihypertensive activity. Spontaneously hypertensive rats (SHR) were randomly assigned to four experimental treatments: (1) 1 mL of 1% methylcellulose by oral gavage and 2% DMSO i.p. (control group); (2) 10 mg kg−1 quercetin by oral gavage once daily and 2% DMSO i.p.; (3) 10 mg kg−1 quercetin by oral gavage divided in two daily doses (5 + 5 at 12 h intervals) and 2% DMSO i.p.; (4) 1 mL of 1% methylcellulose by oral gavage and 10 mg kg−1 quercetin i.p. injection. Rats were treated daily for 5 weeks. Single dose and two daily doses, in a long-term oral treatment were equally efficient, both restoring the impaired aortic endothelium-dependent vasodilatation and reducing mesenteric contractile response to phenylephrine, systolic blood pressure, heart rate, and heart and kidney hypertrophy. Attenuation of vascular NADPH oxidase-driven O2 production was also found in orally treated rats. Intraperitoneal administration reduced, to lesser extent than oral administration, the increased systolic blood pressure, being without effect to the endothelial dysfunction and vascular oxidative stress. In contrast, greater levels of metabolites were quantified following intraperitoneal compared to oral administration at any time point, except for higher plasma methylated quercetin aglycone in oral as compared to intraperitoneal administration at 2 but not at 8 h. In conclusion, oral quercetin was superior to intraperitoneal administration for the protection from cardiovascular complications in SHR. No differences were found between the oral administration as a single daily dose or divided into two daily doses.

Graphical abstract: Different cardiovascular protective effects of quercetin administered orally or intraperitoneally in spontaneously hypertensive rats

Article information

Article type
Paper
Submitted
30 Nov 2011
Accepted
05 Mar 2012
First published
23 Mar 2012

Food Funct., 2012,3, 643-650

Different cardiovascular protective effects of quercetin administered orally or intraperitoneally in spontaneously hypertensive rats

P. Galindo, S. González-Manzano, M. J. Zarzuelo, M. Gómez-Guzmán, A. M. Quintela, A. González-Paramás, C. Santos-Buelga, F. Pérez-Vizcaíno, J. Duarte and R. Jiménez, Food Funct., 2012, 3, 643 DOI: 10.1039/C2FO10268D

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements