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Issue 20, 2012
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Preparation of supramolecular chromophoric assemblies using a DNA duplex

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Organization of supramolecular assemblies of chromophores with precisely-controlled orientation and sequence remains challenging. Nucleic acids with complementary base sequences spontaneously form double-helical structures. Therefore, covalent attachment of chromophores to DNA or RNA can be used to control assembly and orientation of chromophores. In this perspective, we first review our recent work on the assemblies of fluorophores (pyrene and perylene) by using natural base pairs. The interaction between dyes can be strictly controlled by means of cluster and interstrand wedge motifs. We then discuss novel artificial base pairs that can suppress the interaction between fluorophores and nucleobases. We incorporated a cyclohexane moiety into DNA, and showed that these artificial base pairs suppressed the electron–hole transfer between fluorophores and nucleobases and enhanced the quantum yields of fluorophores. These base pairs can potentially be used to accumulate fluorophores inside DNA duplexes without decreasing quantum yields.

Graphical abstract: Preparation of supramolecular chromophoric assemblies using a DNA duplex

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Publication details

The article was received on 20 Feb 2012, accepted on 03 Apr 2012 and first published on 03 Apr 2012

Article type: Perspective
DOI: 10.1039/C2CP40520B
Citation: Phys. Chem. Chem. Phys., 2012,14, 7196-7204
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    Preparation of supramolecular chromophoric assemblies using a DNA duplex

    H. Kashida and H. Asanuma, Phys. Chem. Chem. Phys., 2012, 14, 7196
    DOI: 10.1039/C2CP40520B

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