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Issue 25, 2018
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Formal synthesis of chelamidine alkaloids and their derivatives

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Abstract

A concise two-step operation of α-amination of aldehydes and subsequent Friedel–Crafts/Prins-type cyclization towards accessing tetrahydrobenzo[c]phenanthridine and related structures was developed. The reaction displayed a broad substrate scope and good tolerance to a variety of substituents such as different aromatic heterocyclic rings. In addition, the effectiveness of this protocol was also demonstrated in the formal synthesis of homochelidonine and chelamidine.

Graphical abstract: Formal synthesis of chelamidine alkaloids and their derivatives

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Publication details

The article was received on 26 Dec 2017, accepted on 23 Feb 2018 and first published on 23 Feb 2018


Article type: Communication
DOI: 10.1039/C7CC09875H
Citation: Chem. Commun., 2018,54, 3150-3153
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    Formal synthesis of chelamidine alkaloids and their derivatives

    R. Li, Y. He, Y. Ding, C. Ang, J. Tian and T. Loh, Chem. Commun., 2018, 54, 3150
    DOI: 10.1039/C7CC09875H

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