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Issue 25, 2018
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Copper-catalyzed decarboxylative cyclization via tandem C–P and C–N bond formation: access to 2-phosphorylmethyl indoles

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Abstract

A novel copper-catalyzed decarboxylative cyclization of ethynyl benzoxazinanones with P(O)H compounds has been developed. This protocol leads to a series of 2-phosphorylmethyl indoles with high efficiency and selectivity (up to 99% yield) through tandem C–P/C–N bond formation under mild conditions.

Graphical abstract: Copper-catalyzed decarboxylative cyclization via tandem C–P and C–N bond formation: access to 2-phosphorylmethyl indoles

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Publication details

The article was received on 29 Jan 2018, accepted on 04 Mar 2018 and first published on 07 Mar 2018


Article type: Communication
DOI: 10.1039/C8CC00739J
Citation: Chem. Commun., 2018,54, 3154-3157
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    Copper-catalyzed decarboxylative cyclization via tandem C–P and C–N bond formation: access to 2-phosphorylmethyl indoles

    B. Wang, Y. Wang, M. Zhang, W. Xiao and L. Lu, Chem. Commun., 2018, 54, 3154
    DOI: 10.1039/C8CC00739J

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