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Issue 40, 2017
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CO-Induced apoptotic death of colorectal cancer cells by a luminescent photoCORM grafted on biocompatible carboxymethyl chitosan

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Abstract

A photo-active luminescent rhenium carbonyl complex namely, [Re(CO)3(phen)(pyAl)](CF3SO3) was grafted on a biocompatible carboxymethyl chitosan (CMC) matrix through Schiff base condensation reaction. The light-induced CO delivery from ReCMC has been shown to eradicate human colorectal adenocarcinoma cells (HT-29) very efficiently in a dose-dependent fashion. The onset of CO-induced apoptosis was realized by caspase-3,-7 detection aided by fluorescence confocal microscopy. ReCMC represents a unique example of a biocompatible and biodegradable antineoplastic agent that could find its use in cancer photopharmacology.

Graphical abstract: CO-Induced apoptotic death of colorectal cancer cells by a luminescent photoCORM grafted on biocompatible carboxymethyl chitosan

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Publication details

The article was received on 12 Apr 2017, accepted on 28 Apr 2017 and first published on 28 Apr 2017


Article type: Communication
DOI: 10.1039/C7CC02842C
Citation: Chem. Commun., 2017,53, 5519-5522
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    CO-Induced apoptotic death of colorectal cancer cells by a luminescent photoCORM grafted on biocompatible carboxymethyl chitosan

    I. Chakraborty, J. Jimenez and P. K. Mascharak, Chem. Commun., 2017, 53, 5519
    DOI: 10.1039/C7CC02842C

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