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Issue 40, 2017
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Somatostatin receptor-targeted organometallic iridium(III) complexes as novel theranostic agents

Vojtech Novohradsky,a  Ana Zamora,bc  Albert Gandioso,b  Viktor Brabec,*a  José Ruiz*c  and  Vicente Marchán*b 
Author affiliations

* Corresponding authors

a Institute of Biophysics, Academy of Sciences of the Czech Republic, v.v.i. Kralovopolska 135, 612 65 Brno, Czech Republic
E-mail: brabec@ibp.cz

b Departament de Química Inorgànica i Orgànica, Secció de Química Orgànica, IBUB, Universitat de Barcelona, E-08028 Barcelona, Spain
E-mail: vmarchan@ub.edu

c Departamento de Química Inorgánica, Universidad de Murcia, and Institute for Bio-Health Research of Murcia (IMIB-Arrixaca), E-30071 Murcia, Spain
E-mail: jruiz@um.es

Abstract

A novel somatostatin receptor-targeted anticancer agent based on the conjugation of a highly cytotoxic and luminescent cyclometalated iridium(III) complex to tumor-targeting vectors based on octreotide peptide has been described, and its potential for targeted theranostic applications has been demonstrated.

Graphical abstract: Somatostatin receptor-targeted organometallic iridium(iii) complexes as novel theranostic agents

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Publication details

The article was received on 14 Mar 2017, accepted on 23 Apr 2017 and first published on 25 Apr 2017


Article type: Communication
DOI: 10.1039/C7CC01946G
Citation: Chem. Commun., 2017,53, 5523-5526
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    Somatostatin receptor-targeted organometallic iridium(III) complexes as novel theranostic agents

    V. Novohradsky, A. Zamora, A. Gandioso, V. Brabec, J. Ruiz and V. Marchán, Chem. Commun., 2017, 53, 5523
    DOI: 10.1039/C7CC01946G

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