Issue 62, 2016

Highly solvatochromic and tunable fluorophores based on a 4,5-quinolimide scaffold: novel CDK5 probes

Abstract

Novel 4,5-quinolimide-based fluorophores are more solvatochromic and red-shifted than known naphthalimide analogues. Conjugation of one of these fluorophores to a peptide derived from CDK5 kinase demonstrated its sensitivity for monitoring the interaction with its regulatory partner p25. Introduction of the quinolimide-labelled peptide into living glioblastoma cells probed the interaction with endogenous p25.

Graphical abstract: Highly solvatochromic and tunable fluorophores based on a 4,5-quinolimide scaffold: novel CDK5 probes

Supplementary files

Article information

Article type
Communication
Submitted
31 May 2016
Accepted
29 Jun 2016
First published
29 Jun 2016

Chem. Commun., 2016,52, 9652-9655

Author version available

Highly solvatochromic and tunable fluorophores based on a 4,5-quinolimide scaffold: novel CDK5 probes

J. A. González-Vera, F. Fueyo-González, I. Alkorta, M. Peyressatre, M. C. Morris and R. Herranz, Chem. Commun., 2016, 52, 9652 DOI: 10.1039/C6CC04566A

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