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Issue 46, 2016
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A small synthetic molecule functions as a chloride–bicarbonate dual-transporter and induces chloride secretion in cells

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Abstract

A C2 symmetric small molecule composed of L-phenylalanine and isophthalamide was found to function as a Cl/HCO3 dual transporter and self-assemble into chloride channels. In Ussing-chamber based short-circuit current measurements, this molecule elicited chloride-dependent short-circuit current (Isc) increase in both Calu-3 cell and CFBE41o-cell (with F508del mutant CFTR) monolayers.

Graphical abstract: A small synthetic molecule functions as a chloride–bicarbonate dual-transporter and induces chloride secretion in cells

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Publication details

The article was received on 05 Mar 2016, accepted on 03 May 2016 and first published on 18 May 2016


Article type: Communication
DOI: 10.1039/C6CC01964A
Citation: Chem. Commun., 2016,52, 7380-7383
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    A small synthetic molecule functions as a chloride–bicarbonate dual-transporter and induces chloride secretion in cells

    P. Liu, S. Li, F. Shen, W. Ko, X. Yao and D. Yang, Chem. Commun., 2016, 52, 7380
    DOI: 10.1039/C6CC01964A

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