Issue 81, 2015

N-Substitution dependent stereoselectivity switch in palladium catalyzed hydroalkynylation of ynamides: a regio and stereoselective synthesis of ynenamides

Abstract

A highly general palladium catalysed regioselective hydroalkynylation of ynamides for versatile enamide building blocks with an alkyne tether is achieved with an N-substitution dependent stereoselectivity switch under very mild reaction conditions.

Graphical abstract: N-Substitution dependent stereoselectivity switch in palladium catalyzed hydroalkynylation of ynamides: a regio and stereoselective synthesis of ynenamides

Supplementary files

Article information

Article type
Communication
Submitted
26 Jul 2015
Accepted
11 Aug 2015
First published
12 Aug 2015

Chem. Commun., 2015,51, 14996-14999

N-Substitution dependent stereoselectivity switch in palladium catalyzed hydroalkynylation of ynamides: a regio and stereoselective synthesis of ynenamides

V. Dwivedi, M. Hari Babu, R. Kant and M. Sridhar Reddy, Chem. Commun., 2015, 51, 14996 DOI: 10.1039/C5CC06251A

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