Issue 12, 2015

Guanidinium iodide-catalyzed oxidative α-nitroalkylation of β-ketoamides

Abstract

Oxidative nitroalkylation of β-ketoamides and nitroalkanes, mediated by hypoiodide generated from tert-butyl hydrogen peroxide and a catalytic amount of guanidinium iodide, afforded the corresponding α-nitroalkyl-β-ketoamides in up to 97% yield.

Graphical abstract: Guanidinium iodide-catalyzed oxidative α-nitroalkylation of β-ketoamides

Supplementary files

Article information

Article type
Communication
Submitted
30 Oct 2014
Accepted
17 Dec 2014
First published
18 Dec 2014

Chem. Commun., 2015,51, 2290-2293

Author version available

Guanidinium iodide-catalyzed oxidative α-nitroalkylation of β-ketoamides

K. Yasui, T. Kato, K. Kojima and K. Nagasawa, Chem. Commun., 2015, 51, 2290 DOI: 10.1039/C4CC08581G

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