Issue 34, 2014
From the journal:

Chemical Communications

Two Pb2+-specific DNAzymes with opposite trends in split-site-dependent activity†

Po-Jung Jimmy Huanga  and  Juewen Liu*a  

* Corresponding authors

a Department of Chemistry, Waterloo Institute for Nanotechnology, University of Waterloo, Waterloo, Ontario, Canada
E-mail: liujw@uwaterloo.ca
Fax: +1 519 7460435
Tel: +1 519 8884567 Ext. 38919

Abstract

By splitting the catalytic core of DNAzymes into two halves, two Pb2+-specific DNAzymes retain partial activity, while they show opposite trends of activity as a function of the split site, revealing important nucleotides for catalysis and metal binding.

Graphical abstract: Two Pb2+-specific DNAzymes with opposite trends in split-site-dependent activity

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Article information

DOI
https://doi.org/10.1039/C4CC00864B
Article type
Communication
Submitted
01 Feb 2014
Accepted
04 Mar 2014
First published
04 Mar 2014

Chem. Commun., 2014,50, 4442-4444

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Two Pb2+-specific DNAzymes with opposite trends in split-site-dependent activity

P. J. Huang and J. Liu, Chem. Commun., 2014, 50, 4442 DOI: 10.1039/C4CC00864B

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