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Issue 47, 2012
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Stereo- and regio-selective one-pot synthesis of triazole-based unnatural amino acids and β-amino triazoles

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Abstract

Synthesis of triazole based unnatural amino acids and β-amino triazoles has been described via a stereo and regioselective one-pot multi-component reaction of sulfamidates, sodium azide, and alkynes under MW conditions. The developed method is applicable to a broad substrate scope and has significant potential for the synthesis of unnatural amino acids with a triazole side chain.

Graphical abstract: Stereo- and regio-selective one-pot synthesis of triazole-based unnatural amino acids and β-amino triazoles

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Publication details

The article was received on 02 Apr 2012, accepted on 19 Apr 2012 and first published on 19 Apr 2012


Article type: Communication
DOI: 10.1039/C2CC32392C
Citation: Chem. Commun., 2012,48, 5853-5855
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    Stereo- and regio-selective one-pot synthesis of triazole-based unnatural amino acids and β-amino triazoles

    R. B. N. Baig and R. S. Varma, Chem. Commun., 2012, 48, 5853
    DOI: 10.1039/C2CC32392C

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