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Issue 36, 2011
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Strain-promoted cycloadditions of cyclic nitrones with cyclooctynes for labeling human cancer cells

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Abstract

Strain-promoted cycloadditions of cyclic nitrones with cyclooctynes proceed with rate constants up to 3.38 ± 0.31 M−1 s−1 in CD3CN, or 59 times faster than the analogous reaction of azides. This highly specific modular labeling strategy can be applied for direct labeling of proteins and for live cell imaging of cancer cells.

Graphical abstract: Strain-promoted cycloadditions of cyclic nitrones with cyclooctynes for labeling human cancer cells

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Publication details

The article was received on 26 Jun 2011, accepted on 21 Jul 2011 and first published on 10 Aug 2011


Article type: Communication
DOI: 10.1039/C1CC13808A
Citation: Chem. Commun., 2011,47, 10040-10042
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    Strain-promoted cycloadditions of cyclic nitrones with cyclooctynes for labeling human cancer cells

    C. S. McKay, J. A. Blake, J. Cheng, D. C. Danielson and J. P. Pezacki, Chem. Commun., 2011, 47, 10040
    DOI: 10.1039/C1CC13808A

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