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Issue 36, 2011
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Total synthesis of (−)-nakadomarin A

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Abstract

A highly diastereoselective bifunctional organocatalyst controlled Michael addition, a nitro-Mannich/lactamization cascade, a furanN-acyliminium cyclisation, a sequential alkyne RCM/syn-reduction and an alkene RCM has allowed a 19 step, highly stereoselective synthesis of (−)-nakadomarin A.

Graphical abstract: Total synthesis of (−)-nakadomarin A

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Publication details

The article was received on 20 Jun 2011, accepted on 21 Jul 2011 and first published on 08 Aug 2011


Article type: Communication
DOI: 10.1039/C1CC13665H
Citation: Chem. Commun., 2011,47, 10037-10039
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    Total synthesis of (−)-nakadomarin A

    A. F. Kyle, P. Jakubec, D. M. Cockfield, E. Cleator, J. Skidmore and D. J. Dixon, Chem. Commun., 2011, 47, 10037
    DOI: 10.1039/C1CC13665H

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