Issue 8, 2005
From the journal:

Chemical Communications

Mycobacterium tuberculosis H37Rv3377c encodes the diterpene cyclase for producing the halimane skeleton†

Chiaki Nakano,a   Tomoo Okamura,a   Tsutomu Sato,a   Tohru Dairib  and  Tsutomu Hoshino*a  

* Corresponding authors

a Department of Applied Biological Chemistry, Faculty of Agriculture, and Graduate School of Science and Technology, Niigata University, Ikarashi, Niigata, Japan
E-mail: hoshitsu@agr.niigata-u.ac.jp
Fax: +81-25-262-6854

b Biotechnology Research Center, Toyama Prefectural University, Toyama, Japan

Abstract

The cloning and functional expression of Mycobacterium tuberculosis Rv3377c in Escherichia coli revealed that this gene encodes the diterpene cyclase for producing (+)-5(6),13-halimadiene-15-ol, which accepts geranylgeranyldiphosphate as the intrinsic substrate.

Graphical abstract: Mycobacterium tuberculosis H37Rv3377c encodes the diterpene cyclase for producing the halimane skeleton

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Article information

DOI
https://doi.org/10.1039/B415346D
Article type
Communication
Submitted
04 Oct 2004
Accepted
15 Nov 2004
First published
04 Jan 2005

Chem. Commun., 2005, 1016-1018

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Mycobacterium tuberculosis H37Rv3377c encodes the diterpene cyclase for producing the halimane skeleton

C. Nakano, T. Okamura, T. Sato, T. Dairi and T. Hoshino, Chem. Commun., 2005, 1016 DOI: 10.1039/B415346D

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