Issue 9, 2004

Straightforward synthesis of gem-phosphonate-phosphate containing compounds via one-pot reaction of thioesters with diethyl phosphite

Abstract

A convenient straightforward, three step, one-pot reaction of diethyl phosphite with thioesters in the presence of catalytic amounts of potassium tert-butoxide in toluene or DMF as solvent provided various phosphonate-phosphate containing compounds in excellent yields.

Graphical abstract: Straightforward synthesis of gem-phosphonate-phosphate containing compounds via one-pot reaction of thioesters with diethyl phosphite

Supplementary files

Article information

Article type
Communication
Submitted
23 Jan 2004
Accepted
08 Mar 2004
First published
01 Apr 2004

Chem. Commun., 2004, 1078-1079

Straightforward synthesis of gem-phosphonate-phosphate containing compounds via one-pot reaction of thioesters with diethyl phosphite

K. Pachamuthu and R. R. Schmidt, Chem. Commun., 2004, 1078 DOI: 10.1039/B401079E

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