A two-step, catalytic synthesis of δ-hydroxy-γ-lactones from allylic acetates and bis(trimethylsilyl)ketene acetals
Abstract
Bis(trimethylsilyl) ketene acetals react successively with allylic acetates, in the presence of Pd(0) then with H2O2, in the presence of methyltrioxorhenium, to give δ-hydroxy-γ-lactones via γ-unsaturated carboxylic acids.