Photoredox catalysis in the synthesis of γ- and δ-lactams from N-alkenyl trichloro- and dichloroacetamides

Abstract

The first blue light-mediated synthesis of γ- and δ-lactams from trichloroacetamides is reported in the presence of fac-Ir(ppy)₃. Unlike previous works, these reactions are achieved under an air atmosphere with non-anhydrous solvents and even in water. Moreover, we have demonstrated that the solvent can be the hydrogen donor in the radical process which opens up new insights into these radical transformations and the reaction mechanisms involved.