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Dysohonin A, a meroditerpenoid incorporating a 6,15,6-fused heterotricyclic ring system from Dysoxylum hongkongense

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Abstract

Dysohonin A (1), a meroditerpenoid incorporating an unprecedented 6,15,6-fused heterotricyclic ring system, along with three new biogenetically related meroditerpenoids dysohonins B–D (2–4) were isolated from Dysoxylum hongkongense. Their structures with absolute configurations were well established by a combined method. The plausible biosynthetic pathways of 1–4 were proposed. All the compounds exhibited PTP1B inhibitory activities.

Graphical abstract: Dysohonin A, a meroditerpenoid incorporating a 6,15,6-fused heterotricyclic ring system from Dysoxylum hongkongense

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Publication details

The article was received on 12 May 2018, accepted on 08 Jun 2018 and first published on 13 Jun 2018


Article type: Research Article
DOI: 10.1039/C8QO00469B
Citation: Org. Chem. Front., 2018, Advance Article
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    Dysohonin A, a meroditerpenoid incorporating a 6,15,6-fused heterotricyclic ring system from Dysoxylum hongkongense

    J. Zhao, C. Liu, M. Zhang, J. Li and J. Yue, Org. Chem. Front., 2018, Advance Article , DOI: 10.1039/C8QO00469B

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