Jump to main content
Jump to site search

Issue 14, 2018
Previous Article Next Article

Cobalt-catalyzed directed ortho-methylation of arenes with methyl tosylate

Author affiliations

Abstract

A cobalt-catalyzed directed ortho C–H methylation reaction of arenes has been achieved using readily available methyl tosylate as a methylating agent. An in situ-generated cobalt–N-heterocyclic carbene catalyst in combination with neopentylmagnesium bromide promotes the methylation at room temperature. The reaction is applicable to various substrates bearing nitrogen directing groups such as N-aryl imine, N–H imine, and 2-pyridyl groups. The present protocol also allows for facile introduction of a trideuteriomethyl group into arenes.

Graphical abstract: Cobalt-catalyzed directed ortho-methylation of arenes with methyl tosylate

Back to tab navigation

Supplementary files

Publication details

The article was received on 01 May 2018, accepted on 12 Jun 2018 and first published on 13 Jun 2018


Article type: Research Article
DOI: 10.1039/C8QO00438B
Citation: Org. Chem. Front., 2018,5, 2214-2218
  •   Request permissions

    Cobalt-catalyzed directed ortho-methylation of arenes with methyl tosylate

    Q. Sun and N. Yoshikai, Org. Chem. Front., 2018, 5, 2214
    DOI: 10.1039/C8QO00438B

Search articles by author

Spotlight

Advertisements