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Issue 8, 2018
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Base-promoted [3 + 3] cyclization of cyclopropenones and cyclopropenethiones with amides for the synthesis of 6H-1,3-oxazin-6-ones and 6H-1,3-thiazin-6-ones

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Abstract

A facile synthetic method to access 6H-1,3-oxazin-6-ones and 6H-1,3-thiazin-6-ones has been disclosed via a base-promoted [3 + 3] cyclization reaction of cyclopropenones and cyclopropenethiones with amides. These reactions exhibited excellent yields and good functional group tolerance under metal free and mild conditions.

Graphical abstract: Base-promoted [3 + 3] cyclization of cyclopropenones and cyclopropenethiones with amides for the synthesis of 6H-1,3-oxazin-6-ones and 6H-1,3-thiazin-6-ones

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Publication details

The article was received on 26 Jan 2018, accepted on 26 Feb 2018 and first published on 28 Feb 2018


Article type: Research Article
DOI: 10.1039/C8QO00091C
Citation: Org. Chem. Front., 2018,5, 1267-1271
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    Base-promoted [3 + 3] cyclization of cyclopropenones and cyclopropenethiones with amides for the synthesis of 6H-1,3-oxazin-6-ones and 6H-1,3-thiazin-6-ones

    B. Niu, B. Jiang, L. Yu and M. Shi, Org. Chem. Front., 2018, 5, 1267
    DOI: 10.1039/C8QO00091C

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