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Issue 1, 2016
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Next-generation disulfide stapling: reduction and functional re-bridging all in one

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Abstract

Herein we present a significant step towards next-generation disulfide stapling reagents. A novel class of reagent has been designed to effect both disulfide reduction and functional re-bridging. The strategy has been applied to great success across various peptides and proteins. Moreover, application to a multi-disulfide system resulted in functional re-bridging without disulfide scrambling.

Graphical abstract: Next-generation disulfide stapling: reduction and functional re-bridging all in one

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Publication details

The article was received on 22 Jul 2015, accepted on 13 Sep 2015 and first published on 15 Sep 2015


Article type: Edge Article
DOI: 10.1039/C5SC02666K
Citation: Chem. Sci., 2016,7, 799-802
  • Open access: Creative Commons BY license
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    Next-generation disulfide stapling: reduction and functional re-bridging all in one

    M. T. W. Lee, A. Maruani, J. R. Baker, S. Caddick and V. Chudasama, Chem. Sci., 2016, 7, 799
    DOI: 10.1039/C5SC02666K

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