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Issue 29, 2016
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Insights into the structural patterns of the antileishmanial activity of bi- and tricyclic N-heterocycles

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Abstract

The influence of various structural patterns in a series of novel bi- and tricyclic N-heterocycles on the activity against Leishmania major and Leishmania panamensis has been studied and compounds that are active in the low micromolar region have been identified. Both quinolines and tetrahydrooxazinoindoles (TOI) proved to have significant antileishmanial activities, while substituted indoles were inactive. We have also showed that a chloroquine analogue induces Leishmania killing by modulating macrophage activation.

Graphical abstract: Insights into the structural patterns of the antileishmanial activity of bi- and tricyclic N-heterocycles

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Publication details

The article was received on 26 May 2016, accepted on 27 Jun 2016 and first published on 28 Jun 2016


Article type: Paper
DOI: 10.1039/C6OB01149G
Citation: Org. Biomol. Chem., 2016,14, 7053-7060
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    Insights into the structural patterns of the antileishmanial activity of bi- and tricyclic N-heterocycles

    L. Herrera, D. E. Stephens, A. D'Avila, K. G. George, H. Arman, Y. Zhang, G. Perry, R. Lleonart, O. V. Larionov and P. L. Fernández, Org. Biomol. Chem., 2016, 14, 7053
    DOI: 10.1039/C6OB01149G

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