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Issue 25, 2016
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Total synthesis of desoxycyclomarin C and the cyclomarazines A and B

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Abstract

Removing the β-hydroxy group from the prenylated tryptophan moiety of cyclomarins simplifies the synthesis of these interesting natural products significantly, without having a noteworthy effect on the anti-tuberculosis activity of the cyclomarins. In contrast, cyclomarazines did not show biological activity.

Graphical abstract: Total synthesis of desoxycyclomarin C and the cyclomarazines A and B

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Publication details

The article was received on 14 Apr 2016, accepted on 19 May 2016 and first published on 31 May 2016


Article type: Paper
DOI: 10.1039/C6OB00801A
Citation: Org. Biomol. Chem., 2016,14, 6055-6064
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    Total synthesis of desoxycyclomarin C and the cyclomarazines A and B

    P. Barbie and U. Kazmaier, Org. Biomol. Chem., 2016, 14, 6055
    DOI: 10.1039/C6OB00801A

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