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Issue 3, 2016
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Synthetic approaches towards alkaloids bearing α-tertiary amines

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Abstract

Covering: up to August 2015

Alkaloids account for some of the most beautiful and biologically active natural products. Although they are usually classified along biosynthetic criteria, they can also be categorized according to certain structural motifs. Amongst these, the α-tertiary amine (ATA), i.e. a tetrasubstituted carbon atom surrounded by three carbons and one nitrogen, is particularly interesting. A limited number of methods have been described to access this functional group and fewer still are commonly used in synthesis. Herein, we review some approaches to asymmetrically access ATAs and provide an overview of alkaloid total syntheses where those have been employed.

Graphical abstract: Synthetic approaches towards alkaloids bearing α-tertiary amines

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Publication details

The article was received on 15 Aug 2015, accepted on 29 Oct 2015 and first published on 01 Dec 2015


Article type: Review Article
DOI: 10.1039/C5NP00096C
Citation: Nat. Prod. Rep., 2016,33, 491-522
  • Open access: Creative Commons BY license
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    Synthetic approaches towards alkaloids bearing α-tertiary amines

    A. Hager, N. Vrielink, D. Hager, J. Lefranc and D. Trauner, Nat. Prod. Rep., 2016, 33, 491
    DOI: 10.1039/C5NP00096C

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