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Volume 187, 2016
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Label-free classification of colon cancer grading using infrared spectral histopathology

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Abstract

In recent years spectral histopathology (SHP) has been established as a label-free method to identify cancer within tissue. Herein, this approach is extended. It is not only used to identify tumour tissue with a sensitivity of 94% and a specificity of 100%, but in addition the tumour grading is determined. Grading is a measure of how much the tumour cells differ from the healthy cells. The grading ranges from G1 (well-differentiated), to G2 (moderately differentiated), G3 (poorly differentiated) and in rare cases to G4 (anaplastic). The grading is prognostic and is needed for the therapeutic decision of the clinician. The presented results show good agreement between the annotation by SHP and by pathologists. A correlation matrix is presented, and the results show that SHP provides prognostic values in colon cancer, which are obtained in a label-free and automated manner. It might become an important automated diagnostic tool at the bedside in precision medicine.

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Publication details

The article was received on 10 Nov 2015, accepted on 11 Dec 2015 and first published on 11 Dec 2015


Article type: Paper
DOI: 10.1039/C5FD00157A
Citation: Faraday Discuss., 2016,187, 105-118
  • Open access: Creative Commons BY-NC license
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    Label-free classification of colon cancer grading using infrared spectral histopathology

    C. Kuepper, F. Großerueschkamp, A. Kallenbach-Thieltges, A. Mosig, A. Tannapfel and K. Gerwert, Faraday Discuss., 2016, 187, 105
    DOI: 10.1039/C5FD00157A

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