Radiolabelling with isotopic mixtures of 52g/55Mn(ii) as a straight route to stable manganese complexes for bimodal PET/MR imaging

Abstract

Radiolabelling using isotopic mixtures of ^52g/55Mn(II) offers fast and easy access to new small molecule PET/MR tracers, composed of chemically identical reporting units. trans-1,2-Diaminocyclohexane-N,N,N′,N′-tetraacetic acid (CDTA) was radiolabelled with carrier-added ^52gMn(II) in >99% radiochemical yield, producing the first manganese-based bimodal PET/MR probe. The Mn-CDTA chelate was shown to be very stable to air oxidation and sufficiently inert to decomplexation in blood serum. These data sparked our interest in functionalized CDTA ligands for the design of optimized PET/MR tracers.