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Issue 15, 2016
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Tuning the spontaneous formation kinetics of caffeine : malonic acid co-crystals

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Abstract

It has previously been reported that the caffeine : malonic acid co-crystal system forms spontaneously upon the contact of the two materials. Here we studied the crystal growth in this system to rationally define the role that water plays, thus enabling us to monitor the conversion by solid-state NMR and control the kinetics of spontaneous co-crystal production by increasing or decreasing the relative humidity.

Graphical abstract: Tuning the spontaneous formation kinetics of caffeine : malonic acid co-crystals

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Publication details

The article was received on 11 Feb 2016, accepted on 15 Mar 2016 and first published on 15 Mar 2016


Article type: Communication
DOI: 10.1039/C6CE00353B
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Citation: CrystEngComm, 2016,18, 2617-2620
  • Open access: Creative Commons BY license
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    Tuning the spontaneous formation kinetics of caffeine : malonic acid co-crystals

    K. P. Nartowski, Y. Z. Khimyak and D. J. Berry, CrystEngComm, 2016, 18, 2617
    DOI: 10.1039/C6CE00353B

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