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Issue 62, 2016
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Highly solvatochromic and tunable fluorophores based on a 4,5-quinolimide scaffold: novel CDK5 probes

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Abstract

Novel 4,5-quinolimide-based fluorophores are more solvatochromic and red-shifted than known naphthalimide analogues. Conjugation of one of these fluorophores to a peptide derived from CDK5 kinase demonstrated its sensitivity for monitoring the interaction with its regulatory partner p25. Introduction of the quinolimide-labelled peptide into living glioblastoma cells probed the interaction with endogenous p25.

Graphical abstract: Highly solvatochromic and tunable fluorophores based on a 4,5-quinolimide scaffold: novel CDK5 probes

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Publication details

The article was received on 31 May 2016, accepted on 29 Jun 2016 and first published on 29 Jun 2016


Article type: Communication
DOI: 10.1039/C6CC04566A
Author version available: Download Author version (PDF)
Citation: Chem. Commun., 2016,52, 9652-9655
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    Highly solvatochromic and tunable fluorophores based on a 4,5-quinolimide scaffold: novel CDK5 probes

    J. A. González-Vera, F. Fueyo-González, I. Alkorta, M. Peyressatre, M. C. Morris and R. Herranz, Chem. Commun., 2016, 52, 9652
    DOI: 10.1039/C6CC04566A

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