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Issue 29, 2016
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In situ monitoring of vapour-induced assembly of pharmaceutical cocrystals using a benchtop powder X-ray diffractometer

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Abstract

We describe a simple setup for in situ continuous monitoring of vapour-induced transformations of organic solids using a benchtop powder X-ray diffractometer. Proof-of-principle application of this setup to model pharmaceutical cocrystals reveals complex reactivity, transformations of reaction intermediates within minutes, and a simple route to the rarely observed monoclinic form of the pharmaceutical cocrystal of carbamazepine and saccharin.

Graphical abstract: In situ monitoring of vapour-induced assembly of pharmaceutical cocrystals using a benchtop powder X-ray diffractometer

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Publication details

The article was received on 22 Feb 2016, accepted on 11 Mar 2016 and first published on 14 Mar 2016


Article type: Communication
DOI: 10.1039/C6CC01583B
Citation: Chem. Commun., 2016,52, 5120-5123
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    In situ monitoring of vapour-induced assembly of pharmaceutical cocrystals using a benchtop powder X-ray diffractometer

    I. Huskić, J. Christopherson, K. Užarević and T. Friščić, Chem. Commun., 2016, 52, 5120
    DOI: 10.1039/C6CC01583B

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