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Issue 7, 2016
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A mild hydration of nitriles catalysed by copper(II) acetate

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Abstract

A simple, mild and general procedure for the hydration of nitriles to amides using copper as catalyst and promoted by N,N-diethylhydroxylamine is described. The reaction can be conducted in water at low temperature in short reaction times. This new procedure allows amides to be obtained from a wide range of substrates in excellent yields.

Graphical abstract: A mild hydration of nitriles catalysed by copper(ii) acetate

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Publication details

The article was received on 20 Oct 2015, accepted on 20 Nov 2015 and first published on 20 Nov 2015


Article type: Communication
DOI: 10.1039/C5CC08714G
Author version available: Download Author version (PDF)
Citation: Chem. Commun., 2016,52, 1436-1438
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    A mild hydration of nitriles catalysed by copper(II) acetate

    P. Marcé, J. Lynch, A. J. Blacker and J. M. J. Williams, Chem. Commun., 2016, 52, 1436
    DOI: 10.1039/C5CC08714G

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