Issue 7, 2016

Copper mediated decarboxylative direct C–H arylation of heteroarenes with benzoic acids

Abstract

Decarboxylative coupling reactions to date require a stoichiometric oxidant (such as copper and silver salts) for decarboxylation purposes along with a metal catalyst (e.g. palladium) for cross-coupling. In this communication, an economic and sustainable approach by using a simple copper salt was developed in the presence of molecular oxygen as the sole oxidant. A wide range of 5-membered heteroarenes undergo aryl–heteroaryl cross-coupling with electron deficient aryl carboxylic acids.

Graphical abstract: Copper mediated decarboxylative direct C–H arylation of heteroarenes with benzoic acids

Supplementary files

Article information

Article type
Communication
Submitted
08 Oct 2015
Accepted
17 Nov 2015
First published
17 Nov 2015
This article is Open Access
Creative Commons BY-NC license

Chem. Commun., 2016,52, 1432-1435

Author version available

Copper mediated decarboxylative direct C–H arylation of heteroarenes with benzoic acids

T. Patra, S. Nandi, S. K. Sahoo and D. Maiti, Chem. Commun., 2016, 52, 1432 DOI: 10.1039/C5CC08367B

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence. You can use material from this article in other publications, without requesting further permission from the RSC, provided that the correct acknowledgement is given and it is not used for commercial purposes.

To request permission to reproduce material from this article in a commercial publication, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party commercial publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements