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Issue 12, 2015
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Radiolabeled dendritic probes as tools for high in vivo tumor targeting: application to melanoma

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Abstract

In bioimaging, targeting allows refining the diagnosis by improving the sensitivity and especially the specificity for an earlier diagnosis. Two 111In-radiolabeled dendritic nanoprobes (DPs) (111In-2, 111In-3) and their model counterparts (111In-1, 111In-4) are designed and assessed for in vitro and in vivo tumor targeting efficiency in a murine melanoma models. Tumor uptake is correlated to dendrimer multivalency and reaches values as high as 12.7 ± 1.6% ID g−1 at 4 h post intravenous injection for 111In-3vs. 1.5 ± 0.5% ID g−1 for the unfunctionalized DP, and over 11% ID g−1 for any tumor weight whatsoever.

Graphical abstract: Radiolabeled dendritic probes as tools for high in vivo tumor targeting: application to melanoma

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Publication details

The article was received on 02 Feb 2015, accepted on 18 Feb 2015 and first published on 18 Feb 2015


Article type: Paper
DOI: 10.1039/C5TB00235D
Citation: J. Mater. Chem. B, 2015,3, 2560-2571
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    Radiolabeled dendritic probes as tools for high in vivo tumor targeting: application to melanoma

    A. Parat, D. Kryza, F. Degoul, J. Taleb, C. Viallard, M. Janier, A. Garofalo, P. Bonazza, L. Heinrich-Balard, R. Cohen, E. Miot-Noirault, J. Chezal, C. Billotey and D. Felder-Flesch, J. Mater. Chem. B, 2015, 3, 2560
    DOI: 10.1039/C5TB00235D

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