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Issue 12, 2015
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Periodically tailored titania nanotubes for enhanced drug loading and releasing performances

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Abstract

The structural engineering of titania nanotubes (TNTs) using electrochemical anodization was performed to generate periodically modulated (p-TNTs) internal structures by applying an oscillatory voltage during the anodization process to demonstrate their improved drug-loading and drug-releasing properties. Drug loading and in vitro drug release studies compared with conventional TNTs with flat structures suggested considerable improvement with increased drug loading, reduced burst release and extended drug release for over 2 weeks. Furthermore, p-TNTs arrays were fractured by ultrasonication into liberated TNTs capsules and their potential applications as drug micro/nano-carriers for targeted and localized drug delivery is proposed. The presented electrochemical approach for structural engineering of TNTs provides new prospects in designing TNTs drug releasing implants with advanced drug-loading/release characteristics for localized drug delivery. Such implant modifications can further be tailored to cater for various implant challenges and bone therapies like: inflammation, infection and poor implant integration.

Graphical abstract: Periodically tailored titania nanotubes for enhanced drug loading and releasing performances

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Publication details

The article was received on 14 Nov 2014, accepted on 16 Feb 2015 and first published on 18 Feb 2015


Article type: Paper
DOI: 10.1039/C4TB01882F
Author version available: Download Author version (PDF)
Citation: J. Mater. Chem. B, 2015,3, 2553-2559
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    Periodically tailored titania nanotubes for enhanced drug loading and releasing performances

    K. Gulati, K. Kant, D. Findlay and D. Losic, J. Mater. Chem. B, 2015, 3, 2553
    DOI: 10.1039/C4TB01882F

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