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Issue 10, 2015
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Modular synthesis of dihydro-isoquinolines: palladium-catalyzed sequential C(sp2)–H and C(sp3)–H bond activation

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Abstract

An efficient synthesis of dihydro-isoquinolines via a Pd–catalyzed double C–H bond [a C(sp2)–H and a C(sp3)–H bond] activation/annulation (CHAA) reaction is presented. This methodology features a short reaction time, high atom economy (loss of H2O only) and the formation of a sterically less favoured tertiary C–N bond. This fast (30 min) and environmentally benign radical C–H activation approach has demonstrated the potential direction for the future design/development of fast and efficient C–H direct functionalization processes.

Graphical abstract: Modular synthesis of dihydro-isoquinolines: palladium-catalyzed sequential C(sp2)–H and C(sp3)–H bond activation

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Publication details

The article was received on 23 Apr 2015, accepted on 23 Jun 2015 and first published on 26 Jun 2015


Article type: Edge Article
DOI: 10.1039/C5SC01482D
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Citation: Chem. Sci., 2015,6, 5768-5772
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    Modular synthesis of dihydro-isoquinolines: palladium-catalyzed sequential C(sp2)–H and C(sp3)–H bond activation

    W. Liu, Q. Yu, L. Hu, Z. Chen and J. Huang, Chem. Sci., 2015, 6, 5768
    DOI: 10.1039/C5SC01482D

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