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Issue 47, 2015
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Synthesis, in vitro anticancer activity and SAR studies of arylated imidazo[1,2-a]pyrazine–coumarin hybrids

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Abstract

A new series of imidazo[1,2-a]pyrazine–coumarin hybrids have been synthesized by the combination of two biologically active moieties, imidazo[1,2-a]pyrazine and coumarin, followed by the Suzuki–Miyaura cross coupling reaction for monoarylation at the C6 position and symmetrical/unsymmetrical diarylation at the C3 and C6 positions. These compounds were further screened for their in vitro antitumor activities.

Graphical abstract: Synthesis, in vitro anticancer activity and SAR studies of arylated imidazo[1,2-a]pyrazine–coumarin hybrids

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Publication details

The article was received on 11 Jan 2015, accepted on 07 Apr 2015 and first published on 07 Apr 2015


Article type: Communication
DOI: 10.1039/C5RA00584A
Author version available: Download Author version (PDF)
Citation: RSC Adv., 2015,5, 37887-37895
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    Synthesis, in vitro anticancer activity and SAR studies of arylated imidazo[1,2-a]pyrazine–coumarin hybrids

    R. Goel, V. Luxami and K. Paul, RSC Adv., 2015, 5, 37887
    DOI: 10.1039/C5RA00584A

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