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Issue 11, 2015
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Curcumin and its analogues: a potential natural compound against HIV infection and AIDS

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Abstract

No safe and effective cure currently exists for human immunodeficiency virus (HIV). However, antiretroviral therapy can prolong the lives of HIV patients and lowers the secondary infections. Natural compounds, which are considered to be pleiotropic molecules, could be useful against HIV. Curcumin, a yellow pigment present in the spice turmeric (Curcuma longa), can be used for the treatment of several diseases including HIV-AIDS because of its antioxidant, anti-inflammatory, anticancer, antiviral, and antibacterial nature. In this review we have summarized that how curcumin and its analogues inhibit the infection and replication of viral genes and prevent multiplicity of HIV. They are inhibitors of HIV protease and integrase. Curcumin also inhibits Tat transactivation of the HIV1-LTR genome, inflammatory molecules (interleukins, TNF-α, NF-κB, COX-2) and HIV associated various kinases including tyrosine kinase, PAK1, MAPK, PKC, cdk and others. In addition, curcumin enhances the effect of conventional therapeutic drugs and minimizes their side effects.

Graphical abstract: Curcumin and its analogues: a potential natural compound against HIV infection and AIDS

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Publication details

The article was received on 01 May 2015, accepted on 08 Sep 2015 and first published on 11 Sep 2015


Article type: Review Article
DOI: 10.1039/C5FO00485C
Author version available: Download Author version (PDF)
Citation: Food Funct., 2015,6, 3412-3419
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    Curcumin and its analogues: a potential natural compound against HIV infection and AIDS

    S. Prasad and A. K. Tyagi, Food Funct., 2015, 6, 3412
    DOI: 10.1039/C5FO00485C

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