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Issue 8, 2015
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Convenient detection of metal–DNA, metal–RNA, and metal–protein adducts with a click-modified Pt(II) complex

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Abstract

cis-[Pt(2-azido-1,3-propanediamine)Cl2] is a reagent for high-yield post-treatment fluorescent labelling of Pt(II) biomolecular targets using click chemistry and exhibits a bias in conformational isomers in the context of duplex DNA. Pt–protein adducts are detected using BSA as a model. Following in vivo treatment, long-lived Pt–RNA adducts are detected on ribosomal RNA.

Graphical abstract: Convenient detection of metal–DNA, metal–RNA, and metal–protein adducts with a click-modified Pt(ii) complex

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Publication details

The article was received on 29 Aug 2014, accepted on 08 Oct 2014 and first published on 08 Oct 2014


Article type: Communication
DOI: 10.1039/C4DT02649G
Citation: Dalton Trans., 2015,44, 3536-3539
  • Open access: Creative Commons BY-NC license
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    Convenient detection of metal–DNA, metal–RNA, and metal–protein adducts with a click-modified Pt(II) complex

    A. D. Moghaddam, J. D. White, R. M. Cunningham, A. N. Loes, M. M. Haley and V. J. DeRose, Dalton Trans., 2015, 44, 3536
    DOI: 10.1039/C4DT02649G

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