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Issue 8, 2015
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Zinc complexes as fluorescent chemosensors for nucleic acids: new perspectives for a “boring” element

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Abstract

Zinc(II) complexes are effective and selective nucleic acid-binders and strongly fluorescent molecules in the low energy range, from the visible to the near infrared. These two properties have often been exploited to quantitatively detect nucleic acids in biological samples, in both in vitro and in vivo models. In particular, the fluorescent emission of several zinc(II) complexes is drastically enhanced or quenched by the binding to nucleic acids and/or upon visible light exposure, in a different fashion in bulk solution and when bound to DNA. The twofold objective of this perspective is (1) to review recent utilisations of zinc(II) complexes as selective fluorescent probes for nucleic acids and (2) to highlight their novel potential applications as diagnostic tools based on their photophysical properties.

Graphical abstract: Zinc complexes as fluorescent chemosensors for nucleic acids: new perspectives for a “boring” element

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Publication details

The article was received on 18 Sep 2014, accepted on 21 Oct 2014 and first published on 22 Oct 2014


Article type: Perspective
DOI: 10.1039/C4DT02881C
Author version available: Download Author version (PDF)
Citation: Dalton Trans., 2015,44, 3527-3535
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    Zinc complexes as fluorescent chemosensors for nucleic acids: new perspectives for a “boring” element

    A. Terenzi, A. Lauria, A. M. Almerico and G. Barone, Dalton Trans., 2015, 44, 3527
    DOI: 10.1039/C4DT02881C

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