Jump to main content
Jump to site search

Issue 2, 2015
Previous Article Next Article

Cucurbiturils: from synthesis to high-affinity binding and catalysis

Author affiliations

Abstract

In the wide area of supramolecular chemistry, cucurbit[n]urils (CBn) present themselves as a young family of molecular containers, able to form stable complexes with various guests, including drug molecules, amino acids and peptides, saccharides, dyes, hydrocarbons, perfluorinated hydrocarbons, and even high molecular weight guests such as proteins (e.g., human insulin). Since the discovery of the first CBn, CB6, the field has seen tremendous growth with respect to the synthesis of new homologues and derivatives, the discovery of record binding affinities of guest molecules in their hydrophobic cavity, and associated applications ranging from sensing to drug delivery. In this review, we discuss in detail the fundamental properties of CBn homologues and their cyclic derivatives with a focus on their synthesis and their applications in catalysis.

Graphical abstract: Cucurbiturils: from synthesis to high-affinity binding and catalysis

Back to tab navigation

Publication details

The article was received on 09 Aug 2014 and first published on 15 Oct 2014


Article type: Review Article
DOI: 10.1039/C4CS00273C
Citation: Chem. Soc. Rev., 2015,44, 394-418
  • Open access: Creative Commons BY license
  •   Request permissions

    Cucurbiturils: from synthesis to high-affinity binding and catalysis

    K. I. Assaf and W. M. Nau, Chem. Soc. Rev., 2015, 44, 394
    DOI: 10.1039/C4CS00273C

    This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. Material from this article can be used in other publications provided that the correct acknowledgement is given with the reproduced material.

    Reproduced material should be attributed as follows:

    • For reproduction of material from NJC:
      [Original citation] - Published by The Royal Society of Chemistry (RSC) on behalf of the Centre National de la Recherche Scientifique (CNRS) and the RSC.
    • For reproduction of material from PCCP:
      [Original citation] - Published by the PCCP Owner Societies.
    • For reproduction of material from PPS:
      [Original citation] - Published by The Royal Society of Chemistry (RSC) on behalf of the European Society for Photobiology, the European Photochemistry Association, and RSC.
    • For reproduction of material from all other RSC journals:
      [Original citation] - Published by The Royal Society of Chemistry.

    Information about reproducing material from RSC articles with different licences is available on our Permission Requests page.

Search articles by author

Spotlight

Advertisements