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Issue 38, 2015
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G-quadruplex ligands exhibit differential G-tetrad selectivity

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Abstract

A rapid and simple equilibrium-binding assay mediated by ligand-induced fluorescence quenching of fluorophore-labelled G-quadruplex (G4) structures enabled quantitative interrogation of mutually exclusive ligand binding interactions at opposed G-tetrads. This technique revealed that the ligands TmPyP4, PhenDC3, and PDS have differential chemotype-specific binding preferences for individual G-tetrads of a model genomic G4 structure.

Graphical abstract: G-quadruplex ligands exhibit differential G-tetrad selectivity

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Publication details

The article was received on 17 Mar 2015, accepted on 01 Apr 2015 and first published on 03 Apr 2015


Article type: Communication
DOI: 10.1039/C5CC02252E
Citation: Chem. Commun., 2015,51, 8048-8050
  • Open access: Creative Commons BY license
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    G-quadruplex ligands exhibit differential G-tetrad selectivity

    D. D. Le, M. Di Antonio, L. K. M. Chan and S. Balasubramanian, Chem. Commun., 2015, 51, 8048
    DOI: 10.1039/C5CC02252E

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