Jump to main content
Jump to site search

Issue 38, 2015
Previous Article Next Article

Unprecedented one-pot synthesis of an unsymmetrical cisplatin-based Pt(IV)–acetamidato complex

Author affiliations

Abstract

We describe herein a novel Pt(IV)–acetamidato complex as a result of the one-pot reaction between cisplatin and the highly reactive peroxyacetimidic acid generated in situ. This is the first example of a Pt(IV) complex containing a N-donor ligand coordinated during the Pt(II) → Pt(IV) oxidation step. Remarkably, the Pt(IV)-amidato compound is highly soluble and stable in water; it represents an interesting building block for the further development of Pt(IV) antitumor prodrugs.

Graphical abstract: Unprecedented one-pot synthesis of an unsymmetrical cisplatin-based Pt(iv)–acetamidato complex

Back to tab navigation

Supplementary files

Publication details

The article was received on 25 Mar 2015, accepted on 03 Apr 2015 and first published on 06 Apr 2015


Article type: Communication
DOI: 10.1039/C5CC02477C
Citation: Chem. Commun., 2015,51, 8051-8053
  •   Request permissions

    Unprecedented one-pot synthesis of an unsymmetrical cisplatin-based Pt(IV)–acetamidato complex

    G. Pelosi, M. Ravera, E. Gabano, F. Fregonese and D. Osella, Chem. Commun., 2015, 51, 8051
    DOI: 10.1039/C5CC02477C

Search articles by author

Spotlight

Advertisements