Issue 38, 2015

Unprecedented one-pot synthesis of an unsymmetrical cisplatin-based Pt(iv)–acetamidato complex

Abstract

We describe herein a novel Pt(IV)–acetamidato complex as a result of the one-pot reaction between cisplatin and the highly reactive peroxyacetimidic acid generated in situ. This is the first example of a Pt(IV) complex containing a N-donor ligand coordinated during the Pt(II) → Pt(IV) oxidation step. Remarkably, the Pt(IV)-amidato compound is highly soluble and stable in water; it represents an interesting building block for the further development of Pt(IV) antitumor prodrugs.

Graphical abstract: Unprecedented one-pot synthesis of an unsymmetrical cisplatin-based Pt(iv)–acetamidato complex

Supplementary files

Article information

Article type
Communication
Submitted
25 Mar 2015
Accepted
03 Apr 2015
First published
06 Apr 2015

Chem. Commun., 2015,51, 8051-8053

Unprecedented one-pot synthesis of an unsymmetrical cisplatin-based Pt(IV)–acetamidato complex

G. Pelosi, M. Ravera, E. Gabano, F. Fregonese and D. Osella, Chem. Commun., 2015, 51, 8051 DOI: 10.1039/C5CC02477C

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