Issue 10, 2015
From the journal:

Analyst

Non-derivatized glycan analysis by reverse phase liquid chromatography and ion mobility-mass spectrometry†

Nichole M. Lareau,a   Jody C. Maya  and  John A. McLean*a  

* Corresponding authors

a Department of Chemistry, Center for Innovative Technology, Institute of Chemical Biology, and Institute for Integrative Biosystems Research and Education, Vanderbilt University, 7330 Stevenson Center, Nashville, TN 37235, USA
E-mail: john.a.mclean@vanderbilt.edu
Fax: +1 615-343-1234
Tel: +1 615-322-1195

Abstract

A simple method for the analysis of non-derivatized glycans using a reverse phase column on a liquid chromatography-ion mobility-mass spectrometry (LC-IM-MS) instrument. The methodology supports both glycomic and proteomic work flows without the necessity of switching columns.

Graphical abstract: Non-derivatized glycan analysis by reverse phase liquid chromatography and ion mobility-mass spectrometry

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Article information

DOI
https://doi.org/10.1039/C5AN00152H
Article type
Communication
Submitted
22 Jan 2015
Accepted
20 Feb 2015
First published
23 Feb 2015
This article is Open Access
Creative Commons BY license

Analyst, 2015,140, 3335-3338

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Non-derivatized glycan analysis by reverse phase liquid chromatography and ion mobility-mass spectrometry

N. M. Lareau, J. C. May and J. A. McLean, Analyst, 2015, 140, 3335 DOI: 10.1039/C5AN00152H

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